Antibiotic Response Pattern of Seven (UTI) Infecting Bacteria Isolated from Patients with Urinary Tract Infections Towards 25 Antibiotics

Background: Urinary tract infections (UTIs) impact approximately 150 million people globally each year. Numerous studies indicate a growing prevalence of antibiotic resistance in adults suffering from UTIs. The increase in multidrug-resistant (MDR) bacteria represents a major public health challenge.

Aims: The study aims to elucidate prevalent antibiotic resistance patterns in bacterial urinary pathogens.

Methods: A total of 2028 Uren samples were cultured to assess 25 antibiotics against 7 bacterial genera. Collected data were systematically analyzed. Antibiotic efficacy was determined by the ratio of susceptible to resistant samples across bacterial cultures.

Results: AUGMANTIN (AMC) has emerged as the antibiotic exhibiting the most substantial percentage of sensitivity, attaining an exemplary rate of 84.21% (n = 16) in the framework of the total samples analyzed, whereas OXACILIN (OX) was noted to possess the highest documented rate of resistance, remarkably reaching 100% (n = 10) against E. coli. Furthermore, CEFTAZIDIME (CAZ) demonstrated the pinnacle of sensitivity at 100% (n = 8), succeeded by VANCOMYCIN (VA) recording a sensitivity rate of 90.9% (n = 11), while CIPROFLOXACIN (CIP) and GENTAMYCIN (CN) exhibited total resistance at 100% (n = 4 and 5) against Eitrobacter sp. Conversely, AMIKACIN (AK) and AUGMANTIN (AMC) manifested the highest sensitivity at 100% (n = 13 and 9), whereas AMPICILIN (AMP) and OFLOXACIN (OFX) documented the utmost resistance at 100% (n = 3 and 12) on Klebsiella sp. CEFTRIAXONE (CRO) and NITROFURANTOIN (F) revealed the highest sensitivity at 80% (n = 4 and 8), while CEPHALEXIN (CL), DOXYCYCLINE (DO), and OFLOXACIN (OFX) exhibited complete resistance at 100% (n = 5, 4, and 8 respectively) against Nitrobacteria sp. OXACILIN (OX) demonstrated the highest sensitivity at 87.5% (n = 7), while AZITHROMYCIN (AMZ), CEFIXIME (CFM), CEFTRIAXONE (CRO), CIPROFLOXACIN (CIP), and NITROFURANTOIN (F) recorded a 100% resistance rate (n = 5, 6, 7, 5, and 7 respectively) on Pseudomonas sp. AUGMANTIN (AMC) exhibited the highest sensitivity at an impressive 100% (n = 8), while CEPHALEXIN (CL), OXACILIN (OX), ERYTHROMYCIN (E), and OFLOXACIN (OFX) demonstrated absolute resistance rates of 100% (n = 10, 7, 9, and 10 respectively) against Staphylococcus aureus. Ultimately, OFLOXACIN (OFX) revealed the highest sensitivity rate at 71.42% (n = 5), while CEFIXIME (CFM), OXACILIN (OX), and ERYTHROMYCIN (E) recorded a total resistance rate of 100% (n = 12, 7, and 8 respectively) against Staph hemolytic.